What We Do

With, collectively, over 70 years experience in the Drug Discovery environment we are confident our team can fulfil your needs for any part of the Gene to Structure process.

We tailor our professional services to fit your requirements, whatever stage of the process you are at.

From construct design, through to expression and purification of your desired protein. Whatever your end use, assay, high throughput screening, biophysics or crystallisation and X-ray structure determination, we can supply your protein in a suitable format.

For NMR experiments, we can produce isotopically labelled proteins e.g. 15N and 13C. For de novo structure solution we are equipped to produce SeMet labelled protein.

Peak Proteins’ Services

Image kindly supplied by Oxford Expression Technologies

Protein Expression and Production

We are able to model and engineer a target protein using a variety of software and bioinformatic packages in order to maximise success for a range of different final uses such as screening, different types of structural biology, biophysics and in vivo studies.

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Structural
Determination

X-ray crystallography can reveal details of protein-ligand interactions at the molecular level. We have the facilities and knowledge to crystallise your chosen protein and solve the structure if desired.

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Skilled management of multiple projects ensures a careful balancing of rapid quick turn-around pieces with long-term involvement.

As a team

  • we are accountable for delivery
  • we offer innovative solutions to drive project progression
  • we apply collaborative problem solving
  • we have experience of multiple classes of protein for a wide range of end uses

It is our aim

To keep you informed of the progress at all stages of the project. A central project contact will initiate a start-up meeting, supply regular updates and co-ordinate meetings to discuss progress. Most importantly, we want you to consider us approachable and available to discuss progress, hurdles and any questions at any time, along the way.

The team at a glance

Mark Abbott PhD
Mark Abbott PhD Protein expression and purification specialist
Ian Hampton
Ian Hampton Expert in recombinant protein expression
Tina Howard PhD
Tina Howard PhD Protein crystallisation specialist
Derek Ogg PhD
Derek Ogg PhDProtein crystallography expert
Giles Hassall
Giles HassallProtein purification specialist
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Latest News from Peak Proteins

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New team member, now we are 5!

September 13th, 2016|Comments Off on New team member, now we are 5!

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Giles Hassall has joined us at Peak Proteins on the 1st September.  He is a, much needed, additional skilled pair of hands […]

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X-ray crystal structures of BRD3-fragment complexes presented at EFMC-ISMC 2016

September 5th, 2016|Comments Off on X-ray crystal structures of BRD3-fragment complexes presented at EFMC-ISMC 2016

Peak Proteins presented details of a successful collaboration with Sygnature Discovery at the International Medicinal Chemistry Symposium in Manchester last week.  The project involved looking at the interactions of small molecule fragments with […]

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FEN1-inhibitor co-crystal structure published

August 17th, 2016|Comments Off on FEN1-inhibitor co-crystal structure published

Mark Abbott has recently co-authored a paper in Nature Chemical Biology  as part of a collaboration between AstraZeneca, University of Sheffield and Pelago BioSciences. The publication describes the co-crystal structure of […]