Peak Proteins Blog Archives
AI is undeniably transforming drug discovery: from pinpointing promising disease targets to sketching drug-like molecules, flagging safety risks, and streamlining workflows that once took months into days. The story started from early QSAR models, through the deep-learning boom of [...]
In this mini review we discuss Alpha Synuclein (αSyn), a small, yet curious 140 amino acid long protein that was originally named because of its localisation on synaptic vesicles from the electric lobe of the Pacific Electric Ray, Torpedo [...]
Within Sygnature Protein Science and Structural Biology, our expert Protein Expression Team is central to delivering consistently high-quality, functional proteins for use in drug discovery. This week, we celebrated a major milestone in Protein Science at Sygnature Discovery: the [...]
Over the Summer Sygnature Discovery Protein Science and Structural Biology Department has been busy working with young people in the local community to give an insight into the role of a scientist and what we do as part of [...]
Cryo-EM offers unprecedented insights into complex macromolecules, but success is dependent on the quality of your sample. At Sygnature Discovery, we’ve built a precision-focused cryo-EM lab to ensure your structural biology project starts with the best possible sample. Expertise [...]
If our Membrane Protein Team is one of our superpowers, then our Protein Expression Team are our foundation. Protein Science and Structural Biology at Sygnature would be totally unable to function without this team who are the bedrock of [...]
Have you ever taken a step back from the bench and asked “hang on a minute – how on Earth did we end up using baculovirus infected insect cells to produce recombinant proteins? And more randomly, not just any [...]
We are fortunate at Sygnature Discovery to be one of the few CROs that offer all 3 of the main protein structural biology techniques: X-ray crystallography, cryo-EM and NMR . In this blog we give an overview of how [...]
At Sygnature Discovery, our Protein Science department stands out for its expertise in expressing, purifying and characterising a wide range of proteins to aid assay development, mechanistic studies, and structure-based drug design. Among the most complex and valuable targets [...]
Importance of metabolic GPCRs Metabolic GPCRs play a vital role in how our bodies manage energy. These G protein-coupled receptors act like molecular switches, translating signals from hormones and nutrients into cellular actions that regulate everything from blood sugar [...]
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