We are able to model and engineer a target protein using a variety of software and bioinformatic packages in order to maximise success for a range of different final uses such as screening, different types of structural biology, biophysics and in vivo studies.
We use a wide range of affinity and standard chromatography procedures to allow rapid purification of proteins according to their varied and individual characteristics such as size, charge, hydrophobicity.
Robust QC of all reagents supplied is a key part of the service we offer. Size exclusion chromatography, thermal shift and LC-MS are routinely used to characterise and verify the quality of the purified proteins we produce.
Crystallisation is far from predictable, and going from purified protein to crystals suitable for x-ray analysis can often be an arduous journey. With our extensive experience and knowledge of protein reagents, precipitant factors to vary, and the right experimental set-up to use, we aim to generate diffraction quality crystals as efficiently as possible .