Mark Elvin PhD

Head of Cell Science

Mark has over 22 years research experience in molecular biology, microbiology, biochemistry and industrial biotechnology.

linkedin e1643102876228 google scholar e1643102889326

Dr Mark Elvin | Principal Scientist | Peak Proteins

More about Mark

Mark joins Peak Proteins with over 22 years research experience at both The University of Huddersfield (where he did his degree in Microbial Sciences and his PhD in Microbial Biochemistry), and for the last 18 years as a senior postdoctoral research associate at The University of Manchester. During his academic career at Manchester, Mark has gained experience in the fields of molecular biology, microbiology, biochemistry and industrial biotechnology.

It is during the last 7 years where he has gained extensive experience and knowledge in the expression, production and purification of proteins/enzymes from E. coli, Insect cells (Hi5) and mammalian cells (HEK and CHO cells). Mark also has a keen interest in metabolomics turning this into producing tailored feeds and feeding regimes for cells in order to alleviate metabolic bottlenecks in order to increase protein expression and protein production.

Mark lives over the border in Huddersfield, West Yorkshire (although was born in South Yorkshire) and has been married to his wife Nicola for over 15 years. They have 2 “lively lads" so that keeps them fairly busy with most of their time spent taking them to various activities such as rugby, swimming and scouts. Over the past few years Mark has developed into a keen swimmer, so every day before work he can be found in the local pool swimming up and down. If he has any free time left then on the weekend, he can usually be found on his mountain bike roaming the many hills of Huddersfield!

Long term culture promotes changes to growth, gene expression, and metabolism in CHO cells that are independent of production stability
Biotechnology and Bioengineering, 2023
Torres, M., Betts, Z., Scholey, R., Elvin, M., Place, S., Hayes, A., & Dickson, A. J.

Expanding the HPSE2 Genotypic Spectrum in Urofacial Syndrome, A Disease Featuring a Peripheral Neuropathy of the Urinary Bladder
Frontiers in Genetics , Vol 13, 2022
Beaman Glenda M., Lopes Filipa M., Hofmann Aybike, Roesch Wolfgang, Promm Martin, Bijlsma Emilia K., Patel Chirag, Akinci Aykut, Burgu Berk, Knijnenburg Jeroen, Ho Gladys, Aufschlaeger Christina, Dathe Sylvia, Voelckel Marie Antoinette, Cohen Monika, Yue Wyatt W., Stuart Helen M., Mckenzie Edward A., Elvin Mark, Roberts Neil A., Woolf Adrian S., Newman William G.

VIVID interacts with the WHITE COLLAR complex and FREQUENCY-interacting RNA helicase to alter light and clock responses in Neurospora
Proc. Natl. Acad. Sci., vol. 107, no. 38, pp. 16709–16714, Sep. 2010, doi: 10.1073/pnas.1009474107.
S. M. Hunt, S. Thompson, M. Elvin, and C. Heintzen

The PAS/LOV protein VIVID supports a rapidly dampened daytime oscillator that facilitates entrainment of the Neurospora circadian clock
Genes Dev., vol. 19, no. 21, pp. 2593–2605, Nov. 2005, doi: 10.1101/gad.349305.
M. Elvin, J. J. Loros, J. C. Dunlap, and C. Heintzen

The PAS/LOV protein VIVID controls temperature compensation of circadian clock phase and development in Neurospora crassa
Genes Dev., vol. 21, no. 15, pp. 1964–1974, Aug. 2007, doi: 10.1101/gad.437107.
S. M. Hunt, M. Elvin, S. K. Crosthwaite, and C. Heintzen

A fitness assay for comparing RNAi effects across multiple C. elegans genotypes
BMC Genomics, vol. 12, no. 1, p. 510, Dec. 2011, doi: 10.1186/1471-2164-12-510.
M. Elvin, L. B. Snoek, M. Frejno, U. Klemstein, J. E. Kammenga, and G. B. Poulin

WormQTL—public archive and analysis web portal for natural variation data in Caenorhabditis spp’
Nucleic Acids Res., vol. 41, no. D1, pp. D738–D743, Nov. 2012, doi: 10.1093/nar/gks1124.
L. B. Snoek et al.

Natural Genetic Variation Influences Protein Abundances in C. elegans Developmental Signalling Pathways
PLoS One, vol. 11, no. 3, p. e0149418, Mar. 2016, doi: 10.1371/journal.pone.0149418.
K. D. Singh et al.

Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma
Neuro. Oncol., vol. 22, no. 9, pp. 1289–1301, Sep. 2020, doi: 10.1093/neuonc/noaa051.
J. T. Taylor et al.

reGenotyper: Detecting mislabeled samples in genetic data
PLoS One, vol. 12, no. 2, p. e0171324, Feb. 2017, doi: 10.1371/journal.pone.0171324.
K. Zych et al.

Metabolite Profiling of Mammalian Cell Culture Processes to Evaluate Cellular Viability
2017, pp. 137–152.
I. M. Evie, A. J. Dickson, and M. Elvin

Metabolic profiling of Chinese hamster ovary cell cultures at different working volumes and agitation speeds using spin tube reactors
Biotechnol. Prog., vol. 37, no. 2, Mar. 2021, doi: 10.1002/btpr.3099.
M. Torres, M. Elvin, Z. Betts, S. Place, C. Gaffney, and A. J. Dickson

Temperature-Sensitive and Circadian Oscillators of Neurospora crassa Share Components
Genetics, vol. 191, no. 1, pp. 119–131, May 2012, doi: 10.1534/genetics.111.137976.
S. Hunt, M. Elvin, and C. Heintzen

Metabolite Profiling of Mammalian Cells
Cell Culture Engineering, Wiley, 2019, pp. 251–277.
C. E. Gaffney, A. J. Dickson, and M. Elvin

ACTINOMYCIN-D DOWNREGULATES SOX-2 AND REDUCES TUMOUR GROWTH IN A PRE-CLINICAL MODEL OF GLIOBLASTOMA
Neuro. Oncol., vol. 20, no. suppl_5, pp. v353–v353, Oct. 2018, doi: 10.1093/neuonc/noy129.040.
J. Taylor et al.