Protein Mass Spectrometry

Summary of what we provide

If what you need is not listed below then please contact us, as it is likely that one of our team has experience with the technique you require.

  • Sciex ExionLC  coupled  to  a  Sciex  X500B QTOF  mass 
  • Sciex OS  and  BioPharmaView 
  • Intact mass determination accurate up to 150kDa.
  • Identification of post translational modification mass additions.
  • Covalent compound analysis.
  • Peptide mapping with LC-MSMS for protein identification.
  • Native MS.

Hear from one of our experts

Mark Elvin: Head of Cell Science

“The exquisite accuracy of the mass spec data we are able to produce is often the vital key to explaining exactly what modification has happened to a protein we have produced.”

Tomas Adomavicius: Senior Protein Scientist

Protein Mass Spectrometry Resources

TitleContentCategoriesResources Typeshf:categorieshf:tax:resource_type
Using Mass Spectrometry to Rapidly Facilitate Covalent Drug DiscoveryCase StudyMOREcase-study
An Alternative Method To Confirm Protein BiotinylationCase StudyMOREcase-study
More Papain, More ProblemsCase StudyMOREcase-study
Production of Active Cereblon and Analysis by SPRCase StudyMOREcase-study
In vivo biotinylation of a secreted protein from mammalian cellsCase StudyMOREcase-study
Identification of Novel Post Translational Modifications of a Recombinantly Expressed PeptideCase StudyMOREcase-study
Use of Mass Spectrometry to Assist Production of SARS-CoV-2 Spike Protein CharacterisationRead the recently published Sciex COVID Technote written in collaboration with Sciex. Peptide mapping analysis of COVID-19 spike protein using …, Company NewsMOREpeak-protein-news mass-speccompany-news
IonSource – Mass Spectrometry ResourceComprehensive educational resource for all things Mass spectrometryLinksMOREmass-speclinks
Optimizing Protein Expression and Purification Using Mass Spectrometry Analysis.Listen to the Cell Culture Dish podcast “Optimizing Protein Expression and Purification using Mass Spectrometry Analysis.” The panel discussion with …, VideoMOREmass-spec videosvideo
Reduction and Alkylation of Protein SamplesA method for the reduction and alkylation of protein samples prior to mass spec analysisProtocolMOREmass-specprotocol
Protease InformationProteases are used as tools in protein biochemistry and mass spectrometry experiments. This protocol gives information about their use., ProtocolMOREprotein-purification mass-specprotocol
Mass Spectrometry AidA useful tool summarising masses of amino acids and common modifications found in recombinant proteins.ProtocolMOREmass-specprotocol
Using Peptide Mapping to Reveal Glycosylated and Non-Glycosylated Protein FormsCase StudyMOREcase-study
Liquid Chromatography – Mass Spectrometry Platform: A Wonderful Cure for Protein Science Headaches, MOREpeak-protein-news mass-spec
What Has Mass Spectrometry Ever Done for Us?, MOREblog mass-spec
LC-MS Platform – A Wonderful Cure for Protein Science Headaches.., VideoMOREmass-spec videosvideo
Guilty As ‘Charged’ – Identifying the Protein Using Mass Spectrometry., MOREblog mass-spec