Biotherapeutics and Custom Antibodies
Biotherapeutics
Biotherapeutic Development Support
At Peak Proteins we have many years of experience in supporting the early-stage development of protein based biotherapeutic molecules. Our team has supported biotherapeutic projects involving antibodies, antibody derivatives, chemokines and other protein classes.
Whilst we are not a GLP or GMP facility, we follow Quality by Design principles in taking upstream and downstream laboratory scale processes and modifying them so that they are amenable for manufacture. These are underpinned by Design of Experiments, using JMP software, where appropriate. The ultimate aim is to generate a process that is robust, reproducible, has steps that are scaleable and considers both COSHH and the overall environmental impact. Furthermore, we take into account the cost of goods when designing the process.
During our development experiments we employ mass spectrometry and other analytical techniques with the aim of establishing an early definition of critical quality attributes for your molecule.
In addition, we have a strong track record in providing customers with antigens for their biotherapeutics (including membrane protein targets) along with offering various biophysical techniques to evaluate the antigen / biotherapeutic interaction.
This approach aims to give you the highest chance of delivering a successful biotherapeutic candidate and production process to a CDMO.
Summary of what we provide
If what you need is not listed below then please contact us, as it is likely that one of our team has experience with the technique you require.
Custom Antibodies and Antibody Derivatives
We have experience producing and characterising custom antibodies and derivative forms.
