With a wealth of experience in the Drug Discovery environment, we are confident our team can fulfil your needs for any part of the Gene to Structure process.
We tailor our professional services to fit your requirements, whatever stage of the process you are at. From construct design, through to expression and purification of your desired protein. Whatever your end use, assay, high throughput screening, biophysics or crystallisation and X-ray structure determination, we can supply your protein in a suitable format.
Latest News from Peak Proteins
Unlocking the Structure of G6b-B by Engineering of N- and O-linked Glycosylation.
Read Dr Derek J Ogg's presentation slides from the Protein Structure Determination in Industry Meeting 2019 here Unlocking the structure of G6b-B by engineering of N- and O-linked glycosylation.
Spiders vs Snakes -Discovery of Novel Snake Venom Protease Inhibitors from Spider Venom
Read the poster Venomtech and Peak Proteins presented at ELRIG 2019 here Spiders vs Snakes - Discovery of Novel Snake Venom Protease Inhibitors from Spider Venom On working with Peak [...]
How Was the Structure of G6b-B Determined?
Our journey started, as it often does, with an X-ray crystallography project which looked as if it might be relatively straightforward. The target in question was the extracellular domain (ECD) [...]
Peak Protein Case Studies
Generation of a broad specificity nuclease by refolding of inclusion body expressed protein. Optimisation of downstream processes after cell lysis
Generation of a broad specificity nuclease by refolding of inclusion body expressed protein. Optimisation of downstream processes after cell lysis At Peak Proteins we regularly design DNA constructs for clients, for insertion into mammalian, insect, and bacterial cell systems for over-expression of intracellular proteins. The expressed proteins then [...]
Removing N-linked oligosaccharides to aid protein crystallisation
Removing N-linked oligosaccharides to aid protein crystallisation A client was looking to solve the crystal structure of a secreted protein which contained a number of disulphide bonds and potential N-linked glycosylation sites, which leads to the attachment of complex sugar molecules. There was already literature available describing the [...]
Time critical purification of multiple Fab constructs for assay
Time critical purification of multiple Fab constructs for assay As a leading protein purification company, BiVictriX required us to develop a method to purify 10mg each of 24 different antibody-binding fragments (Fabs) to be tested in assays. Once analysed by BiVictriX, a smaller number of chosen constructs were to [...]