With a wealth of experience in the Drug Discovery environment, we are confident our team can fulfil your needs for any part of the Gene to Structure process.
We tailor our professional services to fit your requirements, whatever stage of the process you are at. From construct design, through to expression and purification of your desired protein. Whatever your end use, assay, high throughput screening, biophysics or crystallisation and X-ray structure determination, we can supply your protein in a suitable format.
Peak Proteins’ Services
We design, express and purify customised proteins reagents to support all stages of the drug discovery process. Our cell and protein scientists have a wealth of experience, many from large pharma organisations. We have many peer reviewed publications describing these techniques. We apply all our expertise and knowledge to your protein, providing an interactive, innovative and flexible approach to every project. Every protein and end use is different. We provide a tailored service, taking the time to understand your specific needs to deliver success. We express proteins using a range of platforms including mammalian HEK293 suspension cells, baculovirus/insect cells, and E. coli.
Our protein structure determination service is driven by an outstanding team of experienced crystallographers with a strong publication record in solving a wide variety of protein structures, including novel ones. A key part of this process is the design of the protein and the ability to screen many different constructs and crystallisation conditions. Our final delivery package is not just a set of co-ordinates. We supply a detailed analysis of the overall 3D structure, along with our learning and conclusions, with ideas for project progression and drug design. Interactive discussions and regular communication with our clients are a key part of our service.
We now provide intact protein and peptide mapping as a stand-alone service to anyone requiring detailed protein or antibody characterisation. Key to this service is the flexibility and quick turnaround times we offer with no detailed contract set-up. Our expert mass spectrometrist, Rachel Rowlinson, will initially discuss your specific needs. Help will be giving with planning and interpretation of the samples analysed and a comprehensive data summary package will be provided with follow-up discussion if required. Whether you have one sample or larger numbers on a regular basis will be reflected in our pricing.
Latest News from Peak Proteins
Presentation at ELRIG R&I meeting
Great to have our poster selected for an oral presentation at this year's ELRIG R&I meeting. G6b-B; a new receptor for platelet formation and function. https://peakproteins.com/wp-content/uploads/2019/03/ELRIG-2019-RI-poster-final.pdf Mark will be describing how [...]
First day of Spring and the Peak Proteins team is growing!
We're delighted to have Raquel Faba Rodríguez join the Peak Proteins team this month. Raquel completed her PhD at the University of East Anglia working on all aspects of X-ray [...]
GPCR structural biology: from stubborn to stress-free
Recently, we’ve been thinking carefully about how we can work with G‑protein coupled receptors (GPCRs), a large class of membrane protein in human that mediate and propagate extracellular stimuli to [...]
Peak Protein Case Studies
Time critical purification of multiple Fab constructs for assay
Time critical purification of multiple Fab constructs for assay As a leading protein purification company, BiVictriX required us to develop a method to purify 10mg each of 24 different antibody-binding fragments (Fabs) to be tested in assays. Once analysed by BiVictriX, a smaller number of chosen constructs were [...]
Adapting use of size exclusion chromatography to improve yields of an unstable, purified protein
Adapting use of size exclusion chromatography to improve yields of an unstable, purified protein A client asked us to express and purify at least 2 mg each of two similar enzymes for selectivity assays. There was literature precedent for both proteins, and a similar approach would be taken [...]
Generation of a Nuclear Receptor Protein with known stability issues for SPR studies
Generation of a Nuclear Receptor with known stability issues for SPR studies Our client needed a nuclear receptor protein for Biacore Surface plasmon resonance (SPR) studies. There was precedent for the production of the protein and was available commercially, but it was well known to have stability issues. [...]