With a wealth of experience in the Drug Discovery environment, we are confident our team can fulfil your needs for any part of the Gene to Structure process.
We tailor our professional services to fit your requirements, whatever stage of the process you are at. From construct design, through to expression and purification of your desired protein. Whatever your end use, assay, high throughput screening, biophysics or crystallisation and X-ray structure determination, we can supply your protein in a suitable format.
Latest News from Peak Proteins
Guilty As ‘Charged’ – Identifying the Protein Using Mass Spectrometry.
At Peak Proteins we routinely use protein mass spectrometry methods to fully characterise and understand the proteins we have produced in our protein expression systems. So why do we do [...]
Dr Hazel Weir is Looking Forward to Attending SLAS 2020
Dr Hazel Weir is attending SLAS 2020. As new members of the Society, Peak Proteins is looking forward to making new connections with biotechnology companies located in the West Coast. [...]
Producing Crystalline Protein-Ligand Complexes: Every Beautiful Partnership Starts with the Introduction.
Why do it? X-ray crystallography of protein-ligand complexes is frequently used during the drug discovery process to determine the molecular details of binding between the chemical entity of interest (ligand) [...]
Peak Protein Case Studies
Generation of a broad specificity nuclease by refolding of inclusion body expressed protein. Optimisation of downstream processes after cell lysis
Generation of a broad specificity nuclease by refolding of inclusion body expressed protein. Optimisation of downstream processes after cell lysis At Peak Proteins we regularly design DNA constructs for clients, for insertion into mammalian, insect, and bacterial cell systems for over-expression of intracellular proteins. The expressed proteins then [...]
Removing N-linked oligosaccharides to aid protein crystallisation
Removing N-linked oligosaccharides to aid protein crystallisation A client was looking to solve the crystal structure of a secreted protein which contained a number of disulphide bonds and potential N-linked glycosylation sites, which leads to the attachment of complex sugar molecules. There was already literature available describing the [...]
Time critical purification of multiple Fab constructs for assay
Time critical purification of multiple Fab constructs for assay As a leading protein purification company, BiVictriX required us to develop a method to purify 10mg each of 24 different antibody-binding fragments (Fabs) to be tested in assays. Once analysed by BiVictriX, a smaller number of chosen constructs were to [...]
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