With a wealth of experience in the Drug Discovery environment, we are confident our team can fulfil your needs for any part of the Gene to Structure process.
We tailor our professional services to fit your requirements, whatever stage of the process you are at. From construct design, through to expression and purification of your desired protein. Whatever your end use, assay, high throughput screening, biophysics or crystallisation and X-ray structure determination, we can supply your protein in a suitable format.
Latest News from Peak Proteins
Peak Proteins Welcomes Roisin Cassidy
Peak Proteins is delighted to welcome Roisin Cassidy to the team. Roisin graduated with a MSci from The University of Manchester in summer this year. Roisin completed an integrated master’s [...]
Peak Proteins Unlocks the Molecular Secrets of a Key Platelet Receptor
The previously unknown structure of the inhibitory platelet receptor, G6b-B has now been solved by Peak Proteins in complex with a glycan ligand similar to that found on perlecan. This [...]
Size Exclusion Chromatography: Size Does Matter
Size exclusion chromatography (SEC), otherwise known as gel filtration chromatography, is one of the simplest and mildest methods of protein separation which is too often thought of as merely a [...]
Peak Protein Case Studies
Removing N-linked oligosaccharides to aid protein crystallisation
Removing N-linked oligosaccharides to aid protein crystallisation A client was looking to solve the crystal structure of a secreted protein which contained a number of disulphide bonds and potential N-linked glycosylation sites, which leads to the attachment of complex sugar molecules. There was already literature available describing the [...]
Time critical purification of multiple Fab constructs for assay
Time critical purification of multiple Fab constructs for assay As a leading protein purification company, BiVictriX required us to develop a method to purify 10mg each of 24 different antibody-binding fragments (Fabs) to be tested in assays. Once analysed by BiVictriX, a smaller number of chosen constructs were to [...]
Adapting use of size exclusion chromatography to improve yields of an unstable, purified protein
Adapting use of size exclusion chromatography to improve yields of an unstable, purified protein A client asked us to express and purify at least 2 mg each of two similar enzymes for selectivity assays. There was literature precedent for both proteins, and a similar approach would be taken with [...]