In the quest to deliver pure recombinant protein for assay, biophysics or crystallisation, the addition of an affinity tag, to fish out the target protein of interest during purification from its crude biological source, is a powerful approach in [...]
A great opportunity this morning for Juli and Rachel to showcase how a combination of protein engineering and detailed mass spectrometry analysis of the expressed proteins can give the insight needed to generate protein crystals of a glycosylated receptor [...]
Kicking off November with a couple of European meetings, starting with Mark attending Europe's biggest life science and pharma partnering meeting, Bio Europe 2018 in Copenhagen. Lots of 1-2-1 meetings lined up!
Peak Proteins will be exhibiting at this year's ELRIG 2018 Drug Discovery conference and running a “Problems with Proteins” drop-in clinic at their booth D5 on Tues 9th. So if you're having problems with expressing, purifying or crystallising proteins, then [...]
Want to know more about factors to consider when expressing proteins in eukaryotic cells? Have a read of Mark Abbott's article from the October issue of European Biopharmaceutical review to learn more https://peakproteins.com/wp-content/uploads/2019/03/EBR-article-peak-proteins.pdf
Despite the recent success of cryoEM in solving more protein structures, X-ray crystallography remains the best method to obtain high resolution (≤3 Angstroms) structures that can facilitate structure-based drug design. However, the method obviously requires the production of ordered, [...]
In a previous blog, we mentioned the theory of Anfinsen that the structure of a protein is determined solely by the amino acid sequence and that this property enables proteins to be refolded in vitro. If this were universally [...]
Have a look at our new Blog Page where we aim to provide helpful thoughts and insights into all aspects of protein expression, purification, crystallography and structure determination... and to mark the event, some creative artwork from Jon Renshaw in our [...]
A warm welcome to Rachel Rowlinson; the latest addition to our expanding team here at Peak Proteins. Rachel has over 20 years experience in the pharmaceutical industry, and brings with her a wealth of experience in protein mass spectrometry, N-terminal protein sequencing [...]
Fragment-based lead generation (FBLG) is a very popular paradigm for early hit identification and lead generation and can be an attractive alternative to the more traditional high-throughput screening (HTS) methods. An interesting example of this was recently published in Nature [...]
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Peak Proteins is a trading name of Sygnature Discovery Limited
