Peak Proteins Blog Archives
Did you know freezers are some of the most energy intensive pieces of equipment found in the lab? An ultralow temperature (ULT) freezer can consume nearly double the amount of electricity as the average 4-bedroom household per day!* Correctly [...]
Scott Allen talks us through his recent Professional Internship for PhD Students (PIPS) placement Over the past three months, I’ve been based at Peak Proteins (part of Sygnature Discovery), completing my PIPS placement. The PIPS scheme is an essential [...]
In this article we discuss the three techniques used for determining protein and nucleic acid structures, their individual merits, what each workflows looks like, and how they fit into drug discovery. Introduction Understanding protein structures is fundamental for unravelling [...]
In this article we discuss O-linked glycosylation of proteins and show some data from a study with the platelet receptor G6b-B to exemplify how we approach identifying the sites of sugar attachment. Glycosylation is a common post-translational modification of [...]
The intriguing world of the Intrinsically disordered proteins and why they are important as targets for drug discovery By Ariadna Juarez-Martinez PhD When we think about proteins, we usually picture them as having a well-defined, three-dimensional, globular shape; however, [...]
In recent years, structural biology has become more prevalent in biotherapeutic development playing a pivotal role in elucidating the antibody-antigen complex formation and understanding the effect on structure of introducing amino acid substitutions. By employing techniques such as X-ray [...]
Following on from our more general blog, “Protein and the Planet” where we reviewed various examples of how protein biotechnology is having an impact as solutions to Climate Change, in this blog Sam Bloor focuses on the directed evolution [...]
Heather Hayes, one of our Green Team here at Peak Proteins gives an update on our efforts to reduce the amount of single use plastic we use. Did you know that an estimated 5.5 million tonnes of plastic waste [...]
Ben’s PIPs Placement Journey with Peak Proteins In this article PhD Student Ben Nash discusses his 3-month PIPs placement work at Peak Proteins, which involved the expression and purification optimisation of the G-protein coupled receptor (GPCR) 5-HT2AR. Ultimately, Ben’s [...]
By Jade Bowen At Peak Proteins, we are often asked to purify a variety of complex and challenging proteins. One of the most difficult targets that we work with are membrane proteins, requiring additional steps and the use of [...]
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