In this mini review we discuss Alpha Synuclein (αSyn), a small, yet curious 140 amino acid long protein that was originally named because of its localisation on synaptic vesicles from the electric lobe of the Pacific Electric Ray, Torpedo [...]
Over the Summer Sygnature Discovery Protein Science and Structural Biology Department has been busy working with young people in the local community to give an insight into the role of a scientist and what we do as part of [...]
If our Membrane Protein Team is one of our superpowers, then our Protein Expression Team are our foundation. Protein Science and Structural Biology at Sygnature would be totally unable to function without this team who are the bedrock of [...]
Have you ever taken a step back from the bench and asked “hang on a minute – how on Earth did we end up using baculovirus infected insect cells to produce recombinant proteins? And more randomly, not just any [...]
We are fortunate at Sygnature Discovery to be one of the few CROs that offer all 3 of the main protein structural biology techniques: X-ray crystallography, cryo-EM and NMR . In this blog we give an overview of how [...]
At Sygnature Discovery, our Protein Science department stands out for its expertise in expressing, purifying and characterising a wide range of proteins to aid assay development, mechanistic studies, and structure-based drug design. Among the most complex and valuable targets [...]
We are growing In 2023, our UK Protein Science and Structural Biology team reached a milestone of 50 members—a moment worth celebrating. But we didn’t want to stop there. This year, we’ve continued to grow, welcoming five exceptional new [...]
Importance of metabolic GPCRs Metabolic GPCRs play a vital role in how our bodies manage energy. These G protein-coupled receptors act like molecular switches, translating signals from hormones and nutrients into cellular actions that regulate everything from blood sugar [...]
By Steven Harborne, Senior Principal Scientist Over the coming months, we’ll be sharing a series of blog posts and case studies that aim to spotlight our work on membrane proteins: from protein production and structural biology to biophysical characterisation [...]
Here we introduce, Margeoux Dela Rosa the latest member of our membrane protein team and we start with Margeoux giving us a brief overview of her scientific journey. "It was the final year of my integrated Masters at the [...]
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