Peak Proteins Protein X Ray Archives
Dr Derek Ogg discusses proteins, structures and how to get them - part of the Medicines Discovery Catapult Connects Webinar Series on Structural Approaches to Drug Discovery - May 2020. (This video has closed captions – if you would [...]
The global covid-19 pandemic is at the forefront of most people’s minds at the moment, and there has been a monumental effort in the scientific community to try and understand every small detail of the enemy down to the [...]
Dr Tina Howard discusses working with SPT Labtech's Mosquito and Dragonfly.
Why do it? X-ray crystallography of protein-ligand complexes is frequently used during the drug discovery process to determine the molecular details of binding between the chemical entity of interest (ligand) and the target protein. This information can be very [...]
Our journey started, as it often does, with an X-ray crystallography project which looked as if it might be relatively straightforward. The target in question was the extracellular domain (ECD) of G6b-B, a unique platelet receptor highly expressed in [...]
Recently, we’ve been thinking carefully about how we can work with G‑protein coupled receptors (GPCRs), a large class of membrane protein in human that mediate and propagate extracellular stimuli to elicit a cellular response. They are involved in sight, [...]
Despite the recent success of cryoEM in solving more protein structures, X-ray crystallography remains the best method to obtain high resolution (≤3 Angstroms) structures that can facilitate structure-based drug design. However, the method obviously requires the production of ordered, [...]
Fragment-based lead generation (FBLG) is a very popular paradigm for early hit identification and lead generation and can be an attractive alternative to the more traditional high-throughput screening (HTS) methods. An interesting example of this was recently published in Nature [...]
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