Biotherapeutics

In this case study we describe the journey to develop a process for the production of the protein component of a biopharmaceutical that was suitable for full scale manufacture. The initial laboratory scale process we were presented with was not fit for purpose and [...]

In this case study Tomas Adomavicius discusses a project where we employed various mass spectrometry techniques to confirm the target API was as expected and also to elucidate the nature of two impurity peaks that were observed during the development of a downstream process [...]

In this case study, Emma Cains and Anna Bennett conducted a series of optimisation experiments that led to a ten-fold yield increase of a Biotherapeutic protein. Background Peak Proteins offers CHO, (CHO-3E7) HEK293-6E and HEK Expi293 expression systems for transient mammalian protein production. The [...]

HEK293 6E cells (which we have on license from the National Research Council (NRC) in Canada) are a well-established mammalian expression system used at Peak Proteins for expressing recombinant proteins. In this case study Sarah Beck describes the experiments that Calum Wilson our summer [...]