Peak Proteins Archives for Cryo-EM
Cryo-EM offers unprecedented insights into complex macromolecules, but success is dependent on the quality of your sample. At Sygnature Discovery, we’ve built a precision-focused cryo-EM lab to ensure your structural biology project starts with the best possible sample. Expertise [...]
At Sygnature Discovery, our Protein Science department stands out for its expertise in expressing, purifying and characterising a wide range of proteins to aid assay development, mechanistic studies, and structure-based drug design. Among the most complex and valuable targets [...]
Importance of metabolic GPCRs Metabolic GPCRs play a vital role in how our bodies manage energy. These G protein-coupled receptors act like molecular switches, translating signals from hormones and nutrients into cellular actions that regulate everything from blood sugar [...]
By Steven Harborne, Senior Principal Scientist Over the coming months, we’ll be sharing a series of blog posts and case studies that aim to spotlight our work on membrane proteins: from protein production and structural biology to biophysical characterisation [...]
In this article we discuss the three techniques used for determining protein and nucleic acid structures, their individual merits, what each workflows looks like, and how they fit into drug discovery. Introduction Understanding protein structures is fundamental for unravelling [...]
In recent years, structural biology has become more prevalent in biotherapeutic development playing a pivotal role in elucidating the antibody-antigen complex formation and understanding the effect on structure of introducing amino acid substitutions. By employing techniques such as X-ray [...]
Following on from our more general blog, “Protein and the Planet” where we reviewed various examples of how protein biotechnology is having an impact as solutions to Climate Change, in this blog Sam Bloor focuses on the directed evolution [...]
Written by Dr. Jack Wright and Dr. Steven Harborne Over the past 5-10 years, there has been an explosion in the field of cryo-electron microscopy (cryo-EM). The resolutions that can be achieved with the latest state-of-the art equipment and [...]
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Peak Proteins is a trading name of Sygnature Discovery Limited
