Peak Proteins Favourites Archives
In this article we discuss the three techniques used for determining protein and nucleic acid structures, their individual merits, what each workflows looks like, and how they fit into drug discovery. Introduction Understanding protein structures is fundamental for unravelling [...]
The intriguing world of the Intrinsically disordered proteins and why they are important as targets for drug discovery By Ariadna Juarez-Martinez PhD When we think about proteins, we usually picture them as having a well-defined, three-dimensional, globular shape; however, [...]
Ben’s PIPs Placement Journey with Peak Proteins In this article PhD Student Ben Nash discusses his 3-month PIPs placement work at Peak Proteins, which involved the expression and purification optimisation of the G-protein coupled receptor (GPCR) 5-HT2AR. Ultimately, Ben’s [...]
By Jade Bowen At Peak Proteins, we are often asked to purify a variety of complex and challenging proteins. One of the most difficult targets that we work with are membrane proteins, requiring additional steps and the use of [...]
Researchers from Peak Proteins (part of Sygnature Discovery Ltd.) have recently published a research paper in the Journal of Visualized Experiments. The paper entitled “Rapid Assessment of Membrane Protein Quality by Fluorescent Size Exclusion Chromatography” was authored by Dr [...]
Protein Structure Determination Being able to determine and visualise the atomic structures of proteins is of invaluable help not only in studying their function but also in aiding the rational design of new potential drugs that target them. One [...]
A perspective on the impact of AI methodology for predicting protein structures from an experimental protein scientist By Dr Steven Harborne The function of a protein is dependent on its three-dimensional structure. Considering that all proteins are formed of [...]
We were asked by Grey Wolf Therapeutics (in collaboration with Sygnature Discovery) to provide support for an endoplasmic reticulum aminopeptidase-1 (ERAP1) drug discovery program. In addition to providing purified ERAP1 proteins for assay, we were also asked to determined X-ray [...]
Fragment-based lead generation (FBLG) is a very popular paradigm for early hit identification and lead generation and can be an attractive alternative to the more traditional high-throughput screening (HTS) methods. An interesting example of this was recently published in Nature [...]
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