Osteikoetxea X, Silva A, Lázaro-Ibáñez E, Salmond N, Shatnyeva O, Stein J, Schick J, Wren S, Lindgren J, Firth M, Madsen A, Mayr LM, Overman R,
Davies R, Dekker N
Engineered Cas9 extracellular vesicles as a novel gene editing tool
J Extracell Vesicles, 2022 May;11(5):e12225, doi: 10.1002/jev2.12225
Hendricks JA, Beaton N, Chernobrovkin A, Miele E, Hamza GM, Ricchiuto P, Tomlinson RC, Friman T, Borenstain C, Barlaam B, Hande S, Lamb ML, De Savi C, Davies R, Main M, Hellner J, Beeler K, Feng Y, Bruderer R, Reiter L, Molina DM, Castaldi MP
Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal Proteomics Methods
ACS Chem Biol, 2022 Jan 21;17(1):54-67, doi: 10.1021
Rutten B, Young S, Aldridge S, Davies R, Fidock M, Newbold P, Singh D, Platt A, Hughes G
The commutability of enzyme linked immunosorbent assays for the quantification of serum eosinophil-derived neurotoxin (EDN), J Immunol Methods. 2022 Jan;500:113181. doi: 10.1016/j.jim.2021.113181
Ding M, Malhotra R, Ottosson T, Lundqvist M, Mebrahtu A, Brengdahl J, Gehrmann U, Bäck E, Ross-Thriepland D, Isaksson I, Magnusson B, Sachsenmeier KF, Tegel H, Hober S, Uhlén M, Mayr LM, Davies R, Rockberg J, Schiavone LH, Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells, Sci Rep. 2021 Aug 18;11(1):16767. doi: 10.1038/s41598-021-96184-z
Ding M, Tegel H, Sivertsson Å, Hober S, Snijder A, Ormö M, Strömstedt PE, Davies R, Holmberg Schiavone L,
Secretome-Based Screening in Target Discovery
SLAS Discov 2020 Jul;25(6):535-551., doi: 10.1177/2472555220917113. Epub 2020 May 19
Davies RA, Holmberg-Schiavone L, Hunt, J, The Development and Use of Protein and Protein-affinity Libraries for Phenotypic Screening, 2020 (Book Chapter), Phenotypic Drug Discovery, Royal Society of Chemistry
Hanna Tegel, Melanie Dannemeyer, Sara Kanje, Åsa Sivertsson, Anna Berling, Anne-Sophie Svensson, Andreas Hober, Henric Enstedt, Anna-Luisa Volk, Magnus Lundqvist, Mona Moradi, Delaram Afshari, Siri Ekblad, LanLan Xu, Malin Westin, Faranak Bidad, Lovisa Holmberg Schiavone, Rick Davies, Lorenz M Mayr, Sinead Knight, Sven O Göpel, Björn G Voldborg, Fredrik Edfors, Björn Forsström, Kalle von Feilitzen, Martin Zwahlen, Johan Rockberg, Jenny Ottosson Takanen, Mathias Uhlén, Sophia Hober
High throughput generation of a resource of the human secretome in mammalian cells
N Biotechnol. 2020 Sep 25;58:45-54
Nikki Heath, Xabier Osteikoetxea, Taiana Mia de Oliveria, Elisa Lázaro-Ibáñez, Olga Shatnyeva, Christina Schindler, Natalie Tigue, Lorenz M Mayr, Niek Dekker, Ross Overman, Rick Davies
Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo
Nanomedicine (Lond). 2019 Nov;14(21):2799-2814
Pavel Macek, Matthew J. Cliff, Kevin J. Embrey, Geoffrey A. Holdgate, J.Willem M.Nissink, Stanislava Panova, Jonathan P.Waltho, Rick A. Davies, Phosphorylation of Myc in the Basic Helix-Loop-Helix Inhibits Binding to Max and DNA via Destabilization of Transient -Helical Structures. 2018, submitted to Journal of Biological Chemistry
Holmberg Schiavone L, Davies RA, Ding M, Karlsson U, Malholtra R, Strömstedt M, Tegel H, Hober S, Sivertsson A, Uhlen M, Identification of secreted protein families that regulate the phenotype of disease relevant cells. 2018 (manuscript in preparation)
Rick A. Davies, Melanie Snow, Jonathan Renshaw, The use of Mass Spectrometry for the characterisation of proteins in small molecule drug discovery. 2017, European Pharmaceutical Review
Rick Davies, Ian Hardern, Ross Overman, 30 years of Protein Production for Small Molecule Drug Discovery. 2016, European Pharmaceutical Review
Murray PG, Read A, Banerjee I, Whatmore AJ, Pritchard LE, Davies RA, Brennand J, White A, Ross RJ, Clayton PE; Reduced appetite and body mass index with delayed puberty in a mother and son: association with a rare novel sequence variant in the leptin gene. 2011, Eur J Endocrinol.164(4):521-7
Gerhardt S, Abbott WM, Hargreaves D, Pauptit RA, Davies RA, Needham MR, Langham C, Barker W, Aziz A, Snow MJ, Dawson S, Welsh F, Wilkinson T, Vaugan T, Beste G, Bishop S, Popovic B, Rees G, Sleeman M, Tuske SJ, Coales SJ, Hamuro Y, Russell C.; Structure of IL-17A in complex with a potent, fully human neutralizing antibody. 2009, J Mol Biol. 394(5):905-21
Ward A, Anderson M, Craggs RI, Maltby J, Grahames C, Davies RA, Finch D, Pattison D, Oakes H, Mallinder PR; E. coli expression and purification of human and cynomolgus IL-15. 2009, Protein Expr Purif.; 68(1):42-8
Cowan RH, Davies RA, Pinheiro TT; A screening system for the identification of refolding conditions for a model protein kinase, p38alpha. 2008, Anal Biochem. 376(1):25-38
Creemers JW, Pritchard LE, Gyte A, Le Rouzic P, Meulemans S, Wardlaw SL, Zhu X, Steiner DF, Davies N, Armstrong D, Lawrence CB, Luckman SM, Schmitz CA, Davies RA, Brennand JC, White A; Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3. 2006, Endocrinology 147(4):1621-31
Brocklehurst KJ, Payne VA, Davies RA, Carroll D, Vertigan HL, Wightman HJ, Aiston S, Waddell ID, Leighton B, Coghlan MP, Agius L, Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators. 2004, Diabetes 53(3):535-41
Katy J Brocklehurst, Rick A Davies, Loranne Agius, Differences in regulatory properties between human and rat glucokinase regulatory protein. 2004, Biochem J. 378(Pt 2): 693–697
