Protein Purification

In this case study Toby Allen demonstrates the value of using multiple analytical methods to characterise Intrinsically Disordered Proteins (IDPs) and highlights some of the techniques we have available at Sygnature Discovery. What are IDPs: While many globular proteins have been characterised with a [...]

In this case study, Rachel Johnson describes how we determined the active state structure of the 5-HT2A receptor with the natural ligand serotonin bound using cryo-EM. Introduction GPCRs are a large and diverse group of receptors in the body. They are also important therapeutic targets [...]

One of our Senior Protein Scientists, Sam Bloor, describes the journey to develop a refolding route for an interleukin. Introduction Cytokines are important cell signalling proteins which bind to cell surface receptors, initiating downstream cascades 1. They have a range of functions such as [...]