Peak Proteins Blog Archives
In general, the bottleneck in determining the structures of proteins using X-ray crystallography is obtaining the well-ordered protein crystals needed to produce high-resolution diffraction data. Often a great deal of time and resource goes into finding the optimal protein [...]
A recombinant protein can be defined as “a modified or manipulated protein encoded by recombinant DNA”. A plasmid containing the gene of interest, in an appropriate expression vector, is expressed in a specific host expression system with the aim [...]
What are post translational modifications? As a protein reaches the final stages of protein synthesis, it undergoes a series of post translational modifications (PTMs) which help define the biophysical characteristics of the final protein. PTMs can be specific to [...]
With apologies to T. S. Eliot The Naming of Proteins is a difficult matter, It isn't just one of your holiday games; You may think at first I'm as mad as a hatter When I tell you, a protein [...]
At Peak Proteins, we use mammalian, insect and bacterial cells grown in specialised culture media for the expression of recombinant proteins. A key focus for us is to ensure the expression systems we use are running optimally, in order [...]
We’re happy to share this recent open access publication out in Nature Scientific Reports: "IMPROvER the Integral Membrane Protein Stability Selector", which was authored by one of our scientists, Dr Steve Harborne. Membrane proteins are often intrinsically flexible, unstable [...]
Mass spectrometry is one of Peak Proteins’ core services. Using the Sciex ExionLC coupled to a Sciex X500B QTOF mass spectrometer with Sciex OS and BioPharmaView Software, we have the ability to perform both LC-MS intact protein analysis along [...]
by Dr. Steven Harborne and Dr. Raquel Faba Rodríguez Peak Proteins is assisting in the fight against COVID-19 by supplying protein reagents for coronavirus research. For example, we are supplying a research team from Trinity College Dublin to help [...]
In a previous blog post, we highlighted some excellent recent work that has elucidated the molecular mechanism of host-cell invasion by the novel 2019 coronavirus (2019-nCoV). Researchers provided us with three-dimensional structures of the viral spike protein using cryoEM. In [...]
In our previous blog post, we explored the solubilisation of membrane proteins in detergent, and explained why this is an important step in the production of pure, stable and active membrane protein product. In short, solubilisation is a process [...]
Peak Proteins
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Email us: info@peakproteins.com
Peak Proteins is a trading name of Sygnature Discovery Limited
