Roberto Maya-Martinez PhD

Lead Scientist and NMR Specialist

Roberto has significant experience gained in academia, especially with studying protein aggregation using different biophysics techniques such as CD, SAXS, TEM, Fluorescence and NMR.

Roberto

More about Roberto

From an early age, Roberto was fascinated by living creatures and the universe and so a career in science was always a likely path. Roberto started his scientific journey at the UAM-I University in Mexico where he studied Experimental Biology, where his fascination in protein biochemistry grew leading to a Masters and then a PhD which focussed on exploring proteins in solution by Nuclear Magnetic Resonance (NMR) at the Morelos Autonomous University in Mexico. It was here that Roberto discovered his love for studying protein structure in solution and during his first post-doctoral research at Institute de Biologie Structurale in Grenoble-France he had the opportunity to combine NMR and SAXS to decipher what was behind the antibiotic resistance in penicillin binding proteins. A second post-doc at the Astbury Centre for Structural Biology at the University of Leeds, UK involved the application of biophysical strategies to investigate protein misfolding and aggregation that occur in most of degenerative diseases. Roberto’s love of science continues to be understanding and investigating steady/ transient/excited states of proteins for potential therapeutic purposes.

In his free time Roberto really enjoys reading, hiking and particularly running, nothing professional just something between 15 to 23Km. Normally, Roberto attempts a couple of half a marathon races during the year, although he doesn’t discard the possibility of running at least one full marathon at some point!

Maya-Martinez R, Xu Y, Guthertz N, Walko M, Karamanos TK, Sobott F, Breeze AL, Radford SE.
Dimers of D76N-β2-microglobulin display potent antiamyloid aggregation activity.
J. Biol. Chem. 2022 Dec;298(12):102659. doi: 10.1016/j.jbc.2022.102659

Ulamec SM, Maya-Martinez R, Byrd EJ, Dewison KM, Xu Y, Willis LF, Sobott F, Heath GR, van Oosten Hawle P, Buchman VL, Radford SE, Brockwell DJ.
Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein.
Nat Commun. 2022 Aug 25;13(1):4986. doi: 10.1038/s41467-022-32687-1

Xu Y, Maya-Martinez R, Guthertz N, Heath GR, Manfield IW, Breeze AL, Sobott F, Foster R, Radford SE.
Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly.
Nat. Commun. 2022 Feb 24;13(1):1040. doi: 10.1038/s41467-022-28660-7

Smith HI, Guthertz N, Cawood EE, Maya-Martinez R, Breeze AL, Radford SE.
The role of the IT-state in D76N β2-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?
J Biol Chem. 2020 Aug 28;295(35):12474-12484. doi: 10.1074/jbc.RA120.014901

Maya-Martinez R, Alexander JAN, Otten CF, Ayala I, Vollmer D, Gray J, Bougault CM, Burt A, Laguri C, Fonvielle M, Arthur M, Strynadka NCJ, Vollmer W, Simorre JP. Recognition of Peptidoglycan Fragments by the Transpeptidase PBP4 From Staphylococcus aureus.
Front. Microbiol. 2019 Jan 18;9:3223. doi: 10.3389/fmicb.2018.03223

Egan AJF, Maya-Martinez R, Ayala I, Bougault CM, Banzhaf M, Breukink E, Vollmer W, Simorre JP.
Induced conformational changes activate the peptidoglycan synthase PBP1B.
Mol Microbiol. 2018 Nov;110(3):335-356. doi: 10.1111/mmi.14082

Maya-Martinez R, Gil-Rodriguez P, Amero C.
Solution structure of 6aJL2 and 6aJL2-R24G amyloidogenics light chain proteins.
Biochem Biophys Res Commun. 2015 Jan 9;456(2):695-9. doi: 10.1016/j.bbrc.2014.12.044