Tony Melarangi PhD

Senior Cell Scientist

Tony Melarangi has significant experience from many years working in the biopharmaceutical industry, mainly focused on Upstream process development.

Tony Melarangi PhD

More about Tony

Tony Melarangi joined Sygnature after spending over 8 years in upstream process development, scale-up and tech transfer at a biologics site in Liverpool.  He worked on gene therapy, plasmid and antibody projects using a range of cell types and bioreactor platforms.

Tony's prior experience includes the generation and characterisation of cardiomyocytes featuring variants of the β2-Adrenoceptor within a stem cell group at the University of Nottingham, and haemato-oncology research at the University of Liverpool, where he completed his PhD in Glucocorticoid resistance in Chronic Lymphocytic Leukaemia.

Tony enjoys cycling and bouldering, reading history, and tries to produce new music from time to time using instruments in which he has varying degrees of proficiency.

AZD8931, an Equipotent, Reversible Inhibitor of Signaling by Epidermal Growth Factor Receptor, ERBB2 (HER2), and ERBB3: A Unique Agent for Simultaneous ERBB Receptor Blockade in Cancer
Clin Cancer Res (2010) 16 (4): 1159–1169.
D. Mark Hickinson; Teresa Klinowska; Georgina Speake; John Vincent; Cath Trigwell; Judith Anderton; Sarah Beck; Gayle Marshall; Sara Davenport; Rowena Callis; Elizabeth Mills; Konstantina Grosios; Paul Smith; Bernard Barlaam; Robert W. Wilkinson; Donald Ogilvie

AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family
Cancer Res (2012) 72 (8): 2045–2056.
Paul R. Gavine; Lorraine Mooney; Elaine Kilgour; Andrew P. Thomas; Katherine Al-Kadhimi; Sarah Beck; Claire Rooney; Tanya Coleman; Dawn Baker; Martine J. Mellor; A. Nigel Brooks; Teresa Klinowska