Peak Proteins Blog Archives
by Head of BD, Hazel Weir. Thinking back on 2022 - a pretty momentous year for Peak Proteins (as well as the rest of the world!) - the story of Charles Dickens’ ‘A Christmas Carol’ came to mind – [...]
Recently we discovered that one of the biggest hits on our website was for our protocol on “Determining Protein Concentration by UV” which is obviously satisfying and we are glad that they are proving to be useful. We are [...]
What is Biotin? Biotin (or vitamin B7) is an essential coenzyme that is required by all organisms for life. Indeed, biotin’s name literally means ‘life giving’. Biotin is covalently linked near the active sites of four major classes of [...]
The first FDA approved recombinant protein therapeutic developed in 1982 was insulin, developed by Genentech/Eli Lilly under the trade name Humulin. E. coli, transformed with recombinant human DNA, was used to express insulin, which was isolated, refolded, and purified. Since [...]
Development of Selective Phosphatidylinositol 5‐Phosphate 4‐Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode Helen K. Boffey, Timothy P. C. Rooney, Henriette M. G. Willems, Simon Edwards, Christopher Green, Tina Howard, Derek Ogg, Tamara Romero, Duncan E. Scott, David [...]
Have you ever thought of using a solubility tag to enhance expression of your protein, considered using SUMO and then wondered, which sequence should I use? and which version is most suitable for the expression host I’m using? It’s [...]
A few months ago, we had a succession of proteins we thought should be well expressed following secretion from the HEK293-6E cell system we use. However, expression was significantly below what we expected making it difficult to supply protein [...]
During 2020’s CASP14 challenge (Critical Assessment of Structure Prediction), Google’s DeepMind showcased Alphafold2, their revised protein folding model, and to say it was impressive is an understatement. The model successfully won the competition with a median Global Distance Test [...]
With over 4 billion people to date (March 2022) having received a Covid-19 vaccination, the human race owes a huge debt to countless researchers, healthcare workers and volunteers. Many of us would not be aware, however, that we also [...]
What are inclusion bodies? Recombinant protein expression has revolutionised biochemical research, allowing the study of protein interaction and function. Here at Peak Proteins, we specialise in the expression and purification of recombinant proteins. The vast majority of proteins in [...]
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