Peak Proteins Blog Archives
One of our newest members of staff, Rahaf Madi, gives her reflections on her first month here with us at Peak Proteins, including the training received and scientific challenges she encountered and how they were solved....teamwork was key to [...]
What is Design of Experiments (DoE) and why use it? Design of Experiments (DoE or sometimes DoX) is an umbrella term that has been coined to cover a particular statistical design and evaluation approach to performing experiments. In essence [...]
Researchers from Peak Proteins (part of Sygnature Discovery Ltd.) have recently published a research paper in the Journal of Visualized Experiments. The paper entitled “Rapid Assessment of Membrane Protein Quality by Fluorescent Size Exclusion Chromatography” was authored by Dr [...]
by Head of BD, Hazel Weir. Thinking back on 2022 - a pretty momentous year for Peak Proteins (as well as the rest of the world!) - the story of Charles Dickens’ ‘A Christmas Carol’ came to mind – [...]
Recently we discovered that one of the biggest hits on our website was for our protocol on “Determining Protein Concentration by UV” which is obviously satisfying and we are glad that they are proving to be useful. We are [...]
What is Biotin? Biotin (or vitamin B7) is an essential coenzyme that is required by all organisms for life. Indeed, biotin’s name literally means ‘life giving’. Biotin is covalently linked near the active sites of four major classes of [...]
The first FDA approved recombinant protein therapeutic developed in 1982 was insulin, developed by Genentech/Eli Lilly under the trade name Humulin. E. coli, transformed with recombinant human DNA, was used to express insulin, which was isolated, refolded, and purified. Since [...]
Development of Selective Phosphatidylinositol 5‐Phosphate 4‐Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode Helen K. Boffey, Timothy P. C. Rooney, Henriette M. G. Willems, Simon Edwards, Christopher Green, Tina Howard, Derek Ogg, Tamara Romero, Duncan E. Scott, David [...]
Have you ever thought of using a solubility tag to enhance expression of your protein, considered using SUMO and then wondered, which sequence should I use? and which version is most suitable for the expression host I’m using? It’s [...]
A few months ago, we had a succession of proteins we thought should be well expressed following secretion from the HEK293-6E cell system we use. However, expression was significantly below what we expected making it difficult to supply protein [...]
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