Case Studies
Our 6 most recent case studies.
See table below for the complete list of all our case studies
All our Case Studies
| Title | Portfolio Categories | hf:tax:portfolio_category |
|---|---|---|
| The key to delivering a FBDD project was optimising the crystal system | X-ray Crystallography | x-ray-crystallography-case-studies |
| Determining the Cryo-EM Structure of the 5-HT2A receptor with Serotonin Bound | Cryo-EM, Membrane Protein, Protein Purification, Protein Science | cryo-em-case-studies membrane-protein-case-studies protein-purification-case-studies protein-science |
| Fragment Screening by Crystallography: An Alternative to High Throughput Screening | X-ray Crystallography | x-ray-crystallography-case-studies |
| Production of Active VHL and Analysis by SPR | Protein Science, FIDA, Mass Spectrometry, SPR | protein-science fida-case-studies mass-spec-case-studies spr |
| Development of a Refolding Protocol for an Interleukin | Protein Purification | protein-purification-case-studies |
| Enhancing Biotherapeutic Protein yield through CHO Expression Optimisation | Protein Expression, Biotherapeutics | protein-expression-case-studies biotherapeutics |
| Using the BacMam System in HEK293-6E cells to Generate High Level Expression of a Membrane Protein | Membrane Protein, Protein Expression | membrane-protein-case-studies protein-expression-case-studies |
| The Journey To Solve a Challenging Protein Purification | Protein Science | protein-science |
| Using Mass Spectrometry to Rapidly Facilitate Covalent Drug Discovery | X-ray Crystallography, Mass Spectrometry, Protein Science | x-ray-crystallography-case-studies mass-spec-case-studies protein-science |
| AlphaFold for fast structural determination of a previously unsolved domain | X-ray Crystallography | x-ray-crystallography-case-studies |
| An Alternative Method To Confirm Protein Biotinylation | Protein Science, Mass Spectrometry | protein-science mass-spec-case-studies |
| Using Design of Experiments to Increase Protein Yield in HEK293 6E cells | Protein Expression, Biotherapeutics | protein-expression-case-studies biotherapeutics |
| More Papain, More Problems | Protein Science, Antibodies, Mass Spectrometry | protein-science antibodies mass-spec-case-studies |
| Production of Active Cereblon and Analysis by SPR | Protein Science, FIDA, Mass Spectrometry, SPR | protein-science fida-case-studies mass-spec-case-studies spr |
| Sometimes a dash of salt is all it takes | Protein Science | protein-science |
| Comparing protein expression in Sf9 and Sf21 insect cells | Protein Expression | protein-expression-case-studies |
| Using Design of Experiments to Improve a Protein Purification Protocol | Protein Science | protein-science |
| Sherlock Holmes and the Case of the Three Missing Amino Acids | Protein Science, Antibodies | protein-science antibodies |
| In vivo biotinylation of a secreted protein from mammalian cells | Protein Expression, Mass Spectrometry, Protein Science | protein-expression-case-studies mass-spec-case-studies protein-science |
| In vivo biotinylation of a challenging target in insect cells | Protein Expression, Protein Science | protein-expression-case-studies protein-science |
| Sherlock Holmes and the Case of the Missing Cysteines. | Protein Science, Antibodies, Protein Expression | protein-science antibodies protein-expression-case-studies |
| Producing Homotrimeric Proteins | Protein Science | protein-science |
| Identification of Novel Post Translational Modifications of a Recombinantly Expressed Peptide | Mass Spectrometry | mass-spec-case-studies |
| The Importance of Protein Construct Design | Protein Science | protein-science |
| Optimising Endoglycosidase H Treatment of Proteins – All Thanks to Cauliflowers! | X-ray Crystallography | x-ray-crystallography-case-studies |
| Using EDTA as a Strategy to Reduce Protein Aggregation | Protein Science | protein-science |
| Method Optimisation and Protein Production for a High Throughput Screen | Protein Science | protein-science |
| Using Peptide Mapping to Reveal Glycosylated and Non-Glycosylated Protein Forms | Mass Spectrometry | mass-spec-case-studies |
| Expression, Purification and Biotinylation of a Heterotrimeric Protein Complex | Protein Expression, Protein Science | protein-expression-case-studies protein-science |
| Preventing Protein Aggregation to Aid Crystallisation | X-ray Crystallography | x-ray-crystallography-case-studies |
| Generation of a broad specificity nuclease by refolding of inclusion body expressed protein. Optimisation of downstream processes after cell lysis | Protein Science | protein-science |
| Removing N-linked Oligosaccharides to Aid Protein Crystallisation | Protein Science, X-ray Crystallography | protein-science x-ray-crystallography-case-studies |
| Time critical purification of multiple Fab constructs for assay | Antibodies, Protein Science | antibodies protein-science |
| Adapting use of size exclusion chromatography to improve yields of an unstable, purified protein | Protein Science | protein-science |
| Generation of a Nuclear Receptor Protein with known stability issues for SPR studies | Protein Science | protein-science |
| Production and analysis of an extensively post-translationally modified secreted protein | Protein Expression, Protein Science | protein-expression-case-studies protein-science |
| Production of a post-translationally modified protein | Protein Expression, Protein Science | protein-expression-case-studies protein-science |
| Generation of a novel, secreted protein for structure determination | Protein Science, X-ray Crystallography | protein-science x-ray-crystallography-case-studies |
